Drug interactions
Levamlodipine + Tacrolimus
Severity: Moderate
Levamlodipine and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levamlodipine, the active enantiomer of amlodipine, may modestly raise tacrolimus blood concentrations. Higher exposure can increase the risk of nephrotoxicity, neurotoxicity and other tacrolimus adverse effects.
What this interaction means in plain words
Levamlodipine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levamlodipine belongs to Cardiovascular; Tacrolimus belongs to Miscellaneous.
Why it happens
Weak inhibition of CYP3A4-mediated tacrolimus metabolism by the dihydropyridine calcium channel blocker is suspected, but the mechanism is not firmly established.
What to do
Monitor tacrolimus trough concentrations and renal function when levamlodipine is started, stopped or changed in dose. Adjust the tacrolimus dose according to trough levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Levamlodipine with Tacrolimus?
MediHelp rates the interaction as moderate. Levamlodipine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levamlodipine, the active enantiomer of amlodipine, may modestly raise tacrolimus blood concentrations. Higher exposure can increase the risk of nephrotoxicity, neurotoxicity and other tacrolimus adverse effects.
How serious is the interaction between Levamlodipine and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough concentrations and renal function when levamlodipine is started, stopped or changed in dose. Adjust the tacrolimus dose according to trough levels.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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