Drug interactions
Levetiracetam + Metoclopramide
Severity: Minor
Levetiracetam and Metoclopramide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, dizziness and mood or behavioural effects. Metoclopramide may also lower seizure threshold, though a meaningful interaction is not well documented.
What this interaction means in plain words
Levetiracetam and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levetiracetam belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive CNS adverse effects; no established pharmacokinetic mechanism.
What to do
Monitor for sedation, behavioural changes and seizure control. No dose adjustment is routinely required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoclopramide
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Metoclopramide?
MediHelp rates the interaction as minor. Levetiracetam and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause somnolence, dizziness and mood or behavioural effects. Metoclopramide may also lower seizure threshold, though a meaningful interaction is not well documented.
How serious is the interaction between Levetiracetam and Metoclopramide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, behavioural changes and seizure control. No dose adjustment is routinely required.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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