Drug interactions
Levetiracetam + Perampanel
Severity: Moderate
Levetiracetam and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both antiseizure drugs cause somnolence, dizziness and gait disturbance, and perampanel in particular is associated with irritability, aggression and mood changes. Levetiracetam can also cause behavioral effects, so combined use may worsen neuropsychiatric adverse effects.
What this interaction means in plain words
Levetiracetam and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Perampanel belongs to Central Nervous System.
Why it happens
Additive CNS adverse effects; perampanel may modestly lower levetiracetam exposure, but the relevance is unclear.
What to do
Titrate perampanel slowly and monitor for sedation, falls, irritability and mood changes. Review the regimen if behavioral symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Levetiracetam with Perampanel?
MediHelp rates the interaction as moderate. Levetiracetam and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both antiseizure drugs cause somnolence, dizziness and gait disturbance, and perampanel in particular is associated with irritability, aggression and mood changes. Levetiracetam can also cause behavioral effects, so combined use may worsen neuropsychiatric adverse effects.
How serious is the interaction between Levetiracetam and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate perampanel slowly and monitor for sedation, falls, irritability and mood changes. Review the regimen if behavioral symptoms emerge.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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