Drug interactions
Levetiracetam + Prochlorperazine
Severity: Moderate
Levetiracetam and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and impaired psychomotor performance. Taken together, sedation and dizziness may be more pronounced, raising the risk of falls and impaired driving.
What this interaction means in plain words
Levetiracetam and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression from two drugs with sedating properties.
What to do
Monitor for excessive sedation and dizziness, particularly at initiation or dose increases. Advise patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Prochlorperazine?
MediHelp rates the interaction as moderate. Levetiracetam and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and impaired psychomotor performance. Taken together, sedation and dizziness may be more pronounced, raising the risk of falls and impaired driving.
How serious is the interaction between Levetiracetam and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and dizziness, particularly at initiation or dose increases. Advise patients to avoid driving until the response is known.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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