Drug interactions
Levetiracetam + Propofol
Severity: Minor
Levetiracetam and Propofol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol is a sedative-hypnotic, and levetiracetam may add to sedation or delay recovery. Levetiracetam is typically continued perioperatively and the combination is generally manageable.
What this interaction means in plain words
Levetiracetam and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levetiracetam belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Continue levetiracetam perioperatively and titrate propofol to effect, monitoring sedation depth and recovery.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levetiracetam
Other interactions of Propofol
Frequently asked questions
Can I take Levetiracetam with Propofol?
MediHelp rates the interaction as minor. Levetiracetam and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propofol is a sedative-hypnotic, and levetiracetam may add to sedation or delay recovery. Levetiracetam is typically continued perioperatively and the combination is generally manageable.
How serious is the interaction between Levetiracetam and Propofol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue levetiracetam perioperatively and titrate propofol to effect, monitoring sedation depth and recovery.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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