Drug interactions
Levofloxacin + Magnesium sulphate
Severity: Moderate
Levofloxacin and Magnesium sulphate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral magnesium reduces levofloxacin absorption by chelation, which can cause subtherapeutic antibiotic exposure and treatment failure. Intravenous magnesium is not affected.
What this interaction means in plain words
Levofloxacin and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Magnesium sulphate belongs to Cardiovascular.
Why it happens
Chelation of levofloxacin by magnesium in the gut reduces its absorption.
What to do
Take oral levofloxacin at least 2 hours before or after oral magnesium preparations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Amphotericin b deoxycholate + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Baloxavir marboxil + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Cisatracurium + Magnesium sulphate Moderate
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Magnesium sulphate?
MediHelp rates the interaction as moderate. Levofloxacin and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral magnesium reduces levofloxacin absorption by chelation, which can cause subtherapeutic antibiotic exposure and treatment failure. Intravenous magnesium is not affected.
How serious is the interaction between Levofloxacin and Magnesium sulphate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take oral levofloxacin at least 2 hours before or after oral magnesium preparations.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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