Drug interactions
Levofloxacin + Vildagliptin
Severity: Minor
Levofloxacin and Vildagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin can disturb glucose control, causing hypoglycemia or hyperglycemia in diabetic patients. Vildagliptin has a low intrinsic hypoglycemia risk, so the effect is mainly unpredictable glucose swings.
What this interaction means in plain words
Levofloxacin and Vildagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levofloxacin belongs to Anti Bacterial; Vildagliptin belongs to Endocrine.
Why it happens
Fluoroquinolones alter pancreatic insulin secretion, which may add to the glucose-lowering effect of vildagliptin.
What to do
Increase blood glucose self-monitoring during the antibiotic course and report symptomatic glucose changes. Switch antibiotic if marked dysglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Vildagliptin
- Ciprofloxacin + Vildagliptin Moderate
- Deflazacort + Vildagliptin Moderate
- Dexamethasone + Vildagliptin Moderate
- Gemifloxacin + Vildagliptin Moderate
- Glimepiride + Vildagliptin Moderate
- Hydrochlorothiazide-lisinopril + Vildagliptin Moderate
Frequently asked questions
Can I take Levofloxacin with Vildagliptin?
MediHelp rates the interaction as minor. Levofloxacin and Vildagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levofloxacin can disturb glucose control, causing hypoglycemia or hyperglycemia in diabetic patients. Vildagliptin has a low intrinsic hypoglycemia risk, so the effect is mainly unpredictable glucose swings.
How serious is the interaction between Levofloxacin and Vildagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase blood glucose self-monitoring during the antibiotic course and report symptomatic glucose changes. Switch antibiotic if marked dysglycemia occurs.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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