Drug interactions
Levoketoconazole + Mycophenolate mofetil
Severity: Minor
Levoketoconazole and Mycophenolate mofetil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole inhibits P-glycoprotein and other transporters, which may raise mycophenolate exposure. This is a predicted effect, and the clinical impact is uncertain. Increased exposure may worsen myelosuppression or gastrointestinal toxicity.
What this interaction means in plain words
Levoketoconazole and Mycophenolate mofetil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levoketoconazole belongs to Endocrine; Mycophenolate mofetil belongs to Miscellaneous.
Why it happens
Predicted inhibition of P-glycoprotein and related transporters by levoketoconazole, increasing mycophenolate exposure.
What to do
Monitor complete blood counts and GI tolerability. Adjust the mycophenolate dose if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Mycophenolate mofetil?
MediHelp rates the interaction as minor. Levoketoconazole and Mycophenolate mofetil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levoketoconazole inhibits P-glycoprotein and other transporters, which may raise mycophenolate exposure. This is a predicted effect, and the clinical impact is uncertain. Increased exposure may worsen myelosuppression or gastrointestinal toxicity.
How serious is the interaction between Levoketoconazole and Mycophenolate mofetil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and GI tolerability. Adjust the mycophenolate dose if adverse effects appear.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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