Drug interactions
Levoketoconazole + Nilutamide
Severity: Moderate
Levoketoconazole and Nilutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilutamide may inhibit CYP3A4 and slightly raise levoketoconazole exposure. Both drugs can cause liver injury, so combined hepatotoxicity is the main practical concern.
What this interaction means in plain words
Levoketoconazole and Nilutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Nilutamide belongs to Endocrine.
Why it happens
Nilutamide may weakly inhibit CYP3A4, and both drugs have additive hepatotoxic potential.
What to do
Monitor liver function tests regularly during coadministration. Stop therapy if significant liver enzyme elevations or symptoms of hepatitis occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilutamide
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Nilutamide?
MediHelp rates the interaction as moderate. Levoketoconazole and Nilutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilutamide may inhibit CYP3A4 and slightly raise levoketoconazole exposure. Both drugs can cause liver injury, so combined hepatotoxicity is the main practical concern.
How serious is the interaction between Levoketoconazole and Nilutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests regularly during coadministration. Stop therapy if significant liver enzyme elevations or symptoms of hepatitis occur.
What other medicines interact with Nilutamide?
MediHelp also lists interactions of Nilutamide with, for example, Dihydroergotamine intranasal, Mavacamten, Artemether / lumefantrine. The full list is on the Nilutamide page.
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