Drug interactions
Levoketoconazole + Norethisterone
Severity: Moderate
Levoketoconazole and Norethisterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and can raise norethisterone concentrations. This may increase progestogenic adverse effects, though norethisterone has a wide margin of safety.
What this interaction means in plain words
Levoketoconazole and Norethisterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Norethisterone belongs to Endocrine.
Why it happens
Strong CYP3A4 inhibition by levoketoconazole reduces norethisterone clearance.
What to do
Monitor for progestogenic adverse effects such as bleeding changes, and reduce the norethisterone dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Norethisterone?
MediHelp rates the interaction as moderate. Levoketoconazole and Norethisterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and can raise norethisterone concentrations. This may increase progestogenic adverse effects, though norethisterone has a wide margin of safety.
How serious is the interaction between Levoketoconazole and Norethisterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects such as bleeding changes, and reduce the norethisterone dose if they occur.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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