Drug interactions
Levoketoconazole + Omeprazole
Severity: Major
Levoketoconazole and Omeprazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole needs gastric acid to dissolve, and omeprazole may markedly reduce its absorption. This may lead to loss of cortisol-lowering effect in Cushing's syndrome.
What this interaction means in plain words
Levoketoconazole and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Levoketoconazole belongs to Endocrine; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH reduces levoketoconazole solubility and absorption.
What to do
Avoid acid-reducing drugs. If antacids are required, take them at least 2 hours after levoketoconazole, and monitor cortisol control.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Omeprazole?
MediHelp rates the interaction as major. Levoketoconazole and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levoketoconazole needs gastric acid to dissolve, and omeprazole may markedly reduce its absorption. This may lead to loss of cortisol-lowering effect in Cushing's syndrome.
How serious is the interaction between Levoketoconazole and Omeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid acid-reducing drugs. If antacids are required, take them at least 2 hours after levoketoconazole, and monitor cortisol control.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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