Drug interactions
Levoketoconazole + Piroxicam
Severity: Moderate
Levoketoconazole and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is an azole antifungal-type enzyme inhibitor that may inhibit CYP2C9 and increase piroxicam levels. Elevated piroxicam exposure could increase gastrointestinal bleeding and renal risk, particularly given its long half-life.
What this interaction means in plain words
Levoketoconazole and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Piroxicam belongs to Musculoskeletal.
Why it happens
Inhibition of CYP2C9-mediated metabolism of piroxicam by levoketoconazole.
What to do
Use the lowest effective piroxicam dose or choose an NSAID less dependent on CYP2C9. Monitor for gastrointestinal bleeding and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Piroxicam?
MediHelp rates the interaction as moderate. Levoketoconazole and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is an azole antifungal-type enzyme inhibitor that may inhibit CYP2C9 and increase piroxicam levels. Elevated piroxicam exposure could increase gastrointestinal bleeding and renal risk, particularly given its long half-life.
How serious is the interaction between Levoketoconazole and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective piroxicam dose or choose an NSAID less dependent on CYP2C9. Monitor for gastrointestinal bleeding and renal function.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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