Drug interactions
Levoketoconazole + Rosuvastatin
Severity: Moderate
Levoketoconazole and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole may increase rosuvastatin exposure, raising the risk of myopathy. The effect is predicted rather than well documented.
What this interaction means in plain words
Levoketoconazole and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Rosuvastatin belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1 and BCRP may reduce rosuvastatin clearance.
What to do
Use the lowest effective rosuvastatin dose and monitor for muscle symptoms. Check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Rosuvastatin?
MediHelp rates the interaction as moderate. Levoketoconazole and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole may increase rosuvastatin exposure, raising the risk of myopathy. The effect is predicted rather than well documented.
How serious is the interaction between Levoketoconazole and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective rosuvastatin dose and monitor for muscle symptoms. Check CK if symptoms occur.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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