Drug interactions
Levoketoconazole + Saxagliptin
Severity: Moderate
Levoketoconazole and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole strongly inhibits CYP3A4 and is expected to raise saxagliptin exposure, as seen with ketoconazole.
What this interaction means in plain words
Levoketoconazole and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Saxagliptin belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 metabolism of saxagliptin.
What to do
Limit saxagliptin to 2.5 mg daily and monitor glucose and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Saxagliptin?
MediHelp rates the interaction as moderate. Levoketoconazole and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole strongly inhibits CYP3A4 and is expected to raise saxagliptin exposure, as seen with ketoconazole.
How serious is the interaction between Levoketoconazole and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit saxagliptin to 2.5 mg daily and monitor glucose and tolerability.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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