Drug interactions
Levoketoconazole + Solifenacin
Severity: Major
Levoketoconazole and Solifenacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and raises solifenacin concentrations substantially. Higher exposure increases anticholinergic effects and QT risk, and levoketoconazole itself prolongs the QT interval.
What this interaction means in plain words
Levoketoconazole and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Levoketoconazole belongs to Endocrine; Solifenacin belongs to Genitourinary.
Why it happens
Strong CYP3A4 inhibition reduces solifenacin clearance, with additive QT effects.
What to do
Do not exceed solifenacin 5 mg daily during treatment and monitor ECG. Consider an alternative to solifenacin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Solifenacin?
MediHelp rates the interaction as major. Levoketoconazole and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levoketoconazole is a strong CYP3A4 inhibitor and raises solifenacin concentrations substantially. Higher exposure increases anticholinergic effects and QT risk, and levoketoconazole itself prolongs the QT interval.
How serious is the interaction between Levoketoconazole and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not exceed solifenacin 5 mg daily during treatment and monitor ECG. Consider an alternative to solifenacin.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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