Drug interactions
Levomilnacipran + Pregabalin
Severity: Minor
Levomilnacipran and Pregabalin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran is generally activating, so a significant additive sedative interaction is not well established. Pregabalin may still cause dizziness and somnolence, and the combination should be monitored.
What this interaction means in plain words
Levomilnacipran and Pregabalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levomilnacipran belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
No well-established mechanism; possible additive CNS effects such as dizziness.
What to do
Monitor for dizziness and somnolence when starting or adjusting either drug. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pregabalin
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Pregabalin?
MediHelp rates the interaction as minor. Levomilnacipran and Pregabalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levomilnacipran is generally activating, so a significant additive sedative interaction is not well established. Pregabalin may still cause dizziness and somnolence, and the combination should be monitored.
How serious is the interaction between Levomilnacipran and Pregabalin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness and somnolence when starting or adjusting either drug. No routine dose change is needed.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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