Drug interactions
Levomilnacipran + Risperidone
Severity: Moderate
Levomilnacipran and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a serotonin-norepinephrine reuptake inhibitor with an antipsychotic can rarely cause serotonin syndrome or neuroleptic malignant syndrome. Levomilnacipran may also raise blood pressure and heart rate.
What this interaction means in plain words
Levomilnacipran and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive serotonergic effects and dopamine blockade, a pharmacodynamic interaction.
What to do
Monitor for agitation, hyperthermia, tremor, rigidity and autonomic instability, especially after dose changes. Stop treatment if serotonin syndrome or neuroleptic malignant syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Risperidone?
MediHelp rates the interaction as moderate. Levomilnacipran and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a serotonin-norepinephrine reuptake inhibitor with an antipsychotic can rarely cause serotonin syndrome or neuroleptic malignant syndrome. Levomilnacipran may also raise blood pressure and heart rate.
How serious is the interaction between Levomilnacipran and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, hyperthermia, tremor, rigidity and autonomic instability, especially after dose changes. Stop treatment if serotonin syndrome or neuroleptic malignant syndrome is suspected.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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