Drug interactions
Levomilnacipran + Rizatriptan
Severity: Moderate
Levomilnacipran and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans combined with serotonin-norepinephrine reuptake inhibitors carry a labeled warning for serotonin syndrome. Cases are uncommon, but symptoms can be severe, including neuromuscular hyperactivity, hyperthermia and altered mental status.
What this interaction means in plain words
Levomilnacipran and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Rizatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic activity from triptan receptor agonism and inhibition of serotonin reuptake by levomilnacipran.
What to do
If used together, counsel the patient about serotonin syndrome symptoms and monitor closely after starting or raising doses. Discontinue the serotonergic drugs if the syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Rizatriptan?
MediHelp rates the interaction as moderate. Levomilnacipran and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptans combined with serotonin-norepinephrine reuptake inhibitors carry a labeled warning for serotonin syndrome. Cases are uncommon, but symptoms can be severe, including neuromuscular hyperactivity, hyperthermia and altered mental status.
How serious is the interaction between Levomilnacipran and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If used together, counsel the patient about serotonin syndrome symptoms and monitor closely after starting or raising doses. Discontinue the serotonergic drugs if the syndrome is suspected.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
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