Drug interactions
Levomilnacipran + Tedizolid
Severity: Moderate
Levomilnacipran and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran is a serotonin and norepinephrine reuptake inhibitor, and tedizolid weakly inhibits MAO. The combination could increase the risk of serotonin syndrome, although tedizolid's serotonergic potential appears lower than linezolid's.
What this interaction means in plain words
Levomilnacipran and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Tedizolid belongs to Anti Bacterial.
Why it happens
Potential additive serotonergic effect from weak MAO inhibition plus reuptake inhibition.
What to do
Monitor for serotonin syndrome symptoms when combining them. Choose an alternative antibiotic if the clinical situation allows.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Levomilnacipran and Tedizolid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Tedizolid?
MediHelp rates the interaction as moderate. Levomilnacipran and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levomilnacipran is a serotonin and norepinephrine reuptake inhibitor, and tedizolid weakly inhibits MAO. The combination could increase the risk of serotonin syndrome, although tedizolid's serotonergic potential appears lower than linezolid's.
How serious is the interaction between Levomilnacipran and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome symptoms when combining them. Choose an alternative antibiotic if the clinical situation allows.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
