Drug interactions
Linagliptin + Lonafarnib
Severity: Minor
Linagliptin and Lonafarnib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a weak P-gp inhibitor and could slightly raise linagliptin levels. Linagliptin is well tolerated at higher exposures, so the effect is unlikely to matter clinically.
What this interaction means in plain words
Linagliptin and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linagliptin belongs to Endocrine; Lonafarnib belongs to Miscellaneous.
Why it happens
Weak P-glycoprotein inhibition by lonafarnib decreases linagliptin efflux.
What to do
No adjustment is generally needed; monitor glucose and tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Linagliptin with Lonafarnib?
MediHelp rates the interaction as minor. Linagliptin and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a weak P-gp inhibitor and could slightly raise linagliptin levels. Linagliptin is well tolerated at higher exposures, so the effect is unlikely to matter clinically.
How serious is the interaction between Linagliptin and Lonafarnib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is generally needed; monitor glucose and tolerability.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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