Drug interactions
Linagliptin + Tipranavir
Severity: Minor
Linagliptin and Tipranavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, inhibits CYP3A4 and P-gp but also induces them over time, so the net effect on linagliptin is unpredictable. Linagliptin has a wide safety margin, so serious toxicity is unlikely.
What this interaction means in plain words
Linagliptin and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linagliptin belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Mixed inhibition and induction of CYP3A4 and P-gp by tipranavir/ritonavir alters linagliptin exposure unpredictably.
What to do
No empirical dose change is needed. Monitor glucose control during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Linagliptin with Tipranavir?
MediHelp rates the interaction as minor. Linagliptin and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tipranavir, given with ritonavir, inhibits CYP3A4 and P-gp but also induces them over time, so the net effect on linagliptin is unpredictable. Linagliptin has a wide safety margin, so serious toxicity is unlikely.
How serious is the interaction between Linagliptin and Tipranavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor glucose control during therapy.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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