Drug interactions
Linagliptin-metformin + Liothyronine
Severity: Moderate
Linagliptin-metformin and Liothyronine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormones increase hepatic glucose output and metabolic rate and may worsen glycemic control in people with diabetes. Dose changes of thyroid hormone can therefore shift antidiabetic requirements.
What this interaction means in plain words
Linagliptin-metformin and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Liothyronine belongs to Endocrine.
Why it happens
Thyroid hormone increases gluconeogenesis, glycogenolysis and glucose absorption, opposing antidiabetic effect.
What to do
Monitor blood glucose when starting or adjusting liothyronine and adjust antidiabetic doses as needed. Watch for hypoglycemia if thyroid hormone is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Linagliptin-metformin with Liothyronine?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormones increase hepatic glucose output and metabolic rate and may worsen glycemic control in people with diabetes. Dose changes of thyroid hormone can therefore shift antidiabetic requirements.
How serious is the interaction between Linagliptin-metformin and Liothyronine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or adjusting liothyronine and adjust antidiabetic doses as needed. Watch for hypoglycemia if thyroid hormone is reduced.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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