Drug interactions
Linagliptin-metformin + Pacritinib
Severity: Moderate
Linagliptin-metformin and Pacritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib inhibits OCT1, which mediates hepatic uptake of metformin and may alter its exposure and effect. The clinical significance is uncertain.
What this interaction means in plain words
Linagliptin-metformin and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Pacritinib belongs to Oncology.
Why it happens
Pacritinib inhibits hepatic OCT1, changing metformin uptake and distribution.
What to do
Monitor glycemic control and for gastrointestinal intolerance. Adjust the metformin dose according to response and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Linagliptin-metformin with Pacritinib?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pacritinib inhibits OCT1, which mediates hepatic uptake of metformin and may alter its exposure and effect. The clinical significance is uncertain.
How serious is the interaction between Linagliptin-metformin and Pacritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and for gastrointestinal intolerance. Adjust the metformin dose according to response and tolerability.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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