Drug interactions
Linagliptin-metformin + Prochlorperazine
Severity: Minor
Linagliptin-metformin and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines such as prochlorperazine can raise blood glucose and may reduce the effect of antidiabetic drugs. Short-term antiemetic use is unlikely to matter much, but prolonged use may.
What this interaction means in plain words
Linagliptin-metformin and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linagliptin-metformin belongs to Endocrine; Prochlorperazine belongs to Central Nervous System.
Why it happens
Phenothiazine-related insulin resistance and reduced insulin secretion oppose glucose lowering.
What to do
Monitor blood glucose if prochlorperazine is used long term and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Linagliptin-metformin with Prochlorperazine?
MediHelp rates the interaction as minor. Linagliptin-metformin and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazines such as prochlorperazine can raise blood glucose and may reduce the effect of antidiabetic drugs. Short-term antiemetic use is unlikely to matter much, but prolonged use may.
How serious is the interaction between Linagliptin-metformin and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if prochlorperazine is used long term and adjust antidiabetic therapy if control worsens.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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