Drug interactions
Linezolid + Propofol
Severity: Minor
Linezolid and Propofol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Evidence of a meaningful interaction is limited. Linezolid is an MAO inhibitor that may increase sensitivity to anesthetic agents and cause hemodynamic lability, but there is no well-established effect on propofol.
What this interaction means in plain words
Linezolid and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linezolid belongs to Anti Bacterial; Propofol belongs to Central Nervous System.
Why it happens
Mechanism is not established; a possible pharmacodynamic additive effect on hemodynamics has been proposed.
What to do
Titrate propofol to effect and monitor blood pressure and heart rate during anesthesia in patients on linezolid.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Linezolid with Propofol?
MediHelp rates the interaction as minor. Linezolid and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Evidence of a meaningful interaction is limited. Linezolid is an MAO inhibitor that may increase sensitivity to anesthetic agents and cause hemodynamic lability, but there is no well-established effect on propofol.
How serious is the interaction between Linezolid and Propofol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect and monitor blood pressure and heart rate during anesthesia in patients on linezolid.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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