Drug interactions
Linezolid + Vilazodone
Severity: Major
Linezolid and Vilazodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone is an SSRI with 5-HT1A partial agonist activity, and linezolid inhibits MAO. The combination can cause serotonin syndrome, and vilazodone labeling advises against its use with MAO inhibitors.
What this interaction means in plain words
Linezolid and Vilazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linezolid belongs to Anti Bacterial; Vilazodone belongs to Central Nervous System.
Why it happens
Serotonin reuptake inhibition with 5-HT1A agonism combined with MAO inhibition.
What to do
Use an alternative antibiotic whenever possible. If linezolid is required, stop vilazodone and monitor for serotonin toxicity, or follow labeling for urgent situations.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Linezolid with Vilazodone?
MediHelp rates the interaction as major. Linezolid and Vilazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vilazodone is an SSRI with 5-HT1A partial agonist activity, and linezolid inhibits MAO. The combination can cause serotonin syndrome, and vilazodone labeling advises against its use with MAO inhibitors.
How serious is the interaction between Linezolid and Vilazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic whenever possible. If linezolid is required, stop vilazodone and monitor for serotonin toxicity, or follow labeling for urgent situations.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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