Drug interactions
Liothyronine + Rifampicin
Severity: Moderate
Liothyronine and Rifampicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin induces hepatic metabolism and can speed elimination of thyroid hormones. Patients may become hypothyroid and need higher replacement doses.
What this interaction means in plain words
Liothyronine and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liothyronine belongs to Endocrine; Rifampicin belongs to Anti Bacterial.
Why it happens
Rifampicin enzyme induction increases hepatic metabolism of liothyronine.
What to do
Monitor TSH and symptoms during and after rifampicin therapy. Raise the liothyronine dose if needed and reduce it again once rifampicin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Liothyronine with Rifampicin?
MediHelp rates the interaction as moderate. Liothyronine and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampicin induces hepatic metabolism and can speed elimination of thyroid hormones. Patients may become hypothyroid and need higher replacement doses.
How serious is the interaction between Liothyronine and Rifampicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor TSH and symptoms during and after rifampicin therapy. Raise the liothyronine dose if needed and reduce it again once rifampicin is stopped.
What other medicines interact with Liothyronine?
MediHelp also lists interactions of Liothyronine with, for example, Alogliptin-metformin, Amitriptyline, Amobarbital. The full list is on the Liothyronine page.
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