Drug interactions
Liothyronine + Saxagliptin-metformin
Severity: Moderate
Liothyronine and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormones increase hepatic glucose production and metabolic rate, which can raise blood glucose and increase antidiabetic requirements. Glucose may fall again if thyroid dose is reduced.
What this interaction means in plain words
Liothyronine and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liothyronine belongs to Endocrine; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through increased gluconeogenesis, glycogenolysis and glucose absorption.
What to do
Monitor blood glucose when starting, changing or stopping liothyronine and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Liothyronine with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Liothyronine and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormones increase hepatic glucose production and metabolic rate, which can raise blood glucose and increase antidiabetic requirements. Glucose may fall again if thyroid dose is reduced.
How serious is the interaction between Liothyronine and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, changing or stopping liothyronine and adjust antidiabetic therapy as needed.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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