Drug interactions
Liothyronine + Sertraline
Severity: Moderate
Liothyronine and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline may increase thyroid hormone requirements in patients taking thyroid replacement, leading to a rise in TSH and hypothyroid symptoms. The effect is variable and reported mainly with levothyroxine.
What this interaction means in plain words
Liothyronine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liothyronine belongs to Endocrine; Sertraline belongs to Central Nervous System.
Why it happens
Possibly enhanced thyroid hormone metabolism by sertraline; the mechanism is not firmly established.
What to do
Check TSH and thyroid status 6 to 8 weeks after starting or changing sertraline. Adjust the liothyronine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Liothyronine with Sertraline?
MediHelp rates the interaction as moderate. Liothyronine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline may increase thyroid hormone requirements in patients taking thyroid replacement, leading to a rise in TSH and hypothyroid symptoms. The effect is variable and reported mainly with levothyroxine.
How serious is the interaction between Liothyronine and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check TSH and thyroid status 6 to 8 weeks after starting or changing sertraline. Adjust the liothyronine dose accordingly.
What other medicines interact with Liothyronine?
MediHelp also lists interactions of Liothyronine with, for example, Alogliptin-metformin, Amitriptyline, Amobarbital. The full list is on the Liothyronine page.
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