Drug interactions
Liposomal doxorubicin + Rucaparib
Severity: Minor
Liposomal doxorubicin and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP3A4 inhibitor in vitro, but doxorubicin relies little on CYP3A4, so a clinically important rise in exposure is unlikely. The two drugs share overlapping myelosuppression, which is the practical concern.
What this interaction means in plain words
Liposomal doxorubicin and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Liposomal doxorubicin belongs to Oncology; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4, a minor route for doxorubicin; additive bone marrow suppression may also occur.
What to do
Monitor blood counts regularly. Adjust doses based on hematologic toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Liposomal doxorubicin with Rucaparib?
MediHelp rates the interaction as minor. Liposomal doxorubicin and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a moderate CYP3A4 inhibitor in vitro, but doxorubicin relies little on CYP3A4, so a clinically important rise in exposure is unlikely. The two drugs share overlapping myelosuppression, which is the practical concern.
How serious is the interaction between Liposomal doxorubicin and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts regularly. Adjust doses based on hematologic toxicity.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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