Drug interactions
Liposomal doxorubicin + Stiripentol
Severity: Minor
Liposomal doxorubicin and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol both inhibits and induces CYP3A4, but doxorubicin is cleared mostly by non-CYP3A4 routes, and the liposomal form even more so. A clinically important change in exposure is unlikely.
What this interaction means in plain words
Liposomal doxorubicin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Liposomal doxorubicin belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP3A4, which has limited importance for doxorubicin elimination.
What to do
No empiric dose change is needed. Monitor for toxicity and treatment response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Liposomal doxorubicin with Stiripentol?
MediHelp rates the interaction as minor. Liposomal doxorubicin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol both inhibits and induces CYP3A4, but doxorubicin is cleared mostly by non-CYP3A4 routes, and the liposomal form even more so. A clinically important change in exposure is unlikely.
How serious is the interaction between Liposomal doxorubicin and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor for toxicity and treatment response.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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