Drug interactions
Liraglutide + Metolazone
Severity: Minor
Liraglutide and Metolazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-type diuretics such as metolazone can worsen glucose tolerance and raise blood glucose. This may partly offset the glucose-lowering effect of liraglutide, particularly at the start of diuretic therapy or after a dose increase.
What this interaction means in plain words
Liraglutide and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Liraglutide belongs to Endocrine; Metolazone belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism: thiazide-induced hypokalemia and reduced insulin sensitivity or secretion oppose the glycemic action of liraglutide.
What to do
Monitor blood glucose and HbA1c when metolazone is started, stopped or its dose changed, and adjust antidiabetic therapy if control worsens. Correct hypokalemia if present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metolazone
Other interactions of Liraglutide
Frequently asked questions
Can I take Liraglutide with Metolazone?
MediHelp rates the interaction as minor. Liraglutide and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide-type diuretics such as metolazone can worsen glucose tolerance and raise blood glucose. This may partly offset the glucose-lowering effect of liraglutide, particularly at the start of diuretic therapy or after a dose increase.
How serious is the interaction between Liraglutide and Metolazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when metolazone is started, stopped or its dose changed, and adjust antidiabetic therapy if control worsens. Correct hypokalemia if present.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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