Drug interactions
Liraglutide + Pegvisomant
Severity: Moderate
Liraglutide and Pegvisomant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvisomant blocks growth hormone receptors, which can improve insulin sensitivity and glucose tolerance in acromegaly. When given with liraglutide, glucose lowering may be greater than expected, raising the chance of hypoglycemia, particularly if other antidiabetic drugs are also used.
What this interaction means in plain words
Liraglutide and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liraglutide belongs to Endocrine; Pegvisomant belongs to Endocrine.
Why it happens
Pharmacodynamic additive glucose lowering through improved insulin sensitivity from growth hormone receptor blockade on top of GLP-1 receptor agonism.
What to do
Monitor blood glucose when pegvisomant is started or its dose changed. Reduce doses of concurrent insulin or sulfonylureas if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liraglutide
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Liraglutide with Pegvisomant?
MediHelp rates the interaction as moderate. Liraglutide and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegvisomant blocks growth hormone receptors, which can improve insulin sensitivity and glucose tolerance in acromegaly. When given with liraglutide, glucose lowering may be greater than expected, raising the chance of hypoglycemia, particularly if other antidiabetic drugs are also used.
How serious is the interaction between Liraglutide and Pegvisomant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when pegvisomant is started or its dose changed. Reduce doses of concurrent insulin or sulfonylureas if hypoglycemia occurs.
What other medicines interact with Liraglutide?
MediHelp also lists interactions of Liraglutide with, for example, Insulin degludec-liraglutide, Insulin glargine-lixisenatide, Alogliptin-metformin. The full list is on the Liraglutide page.
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