Drug interactions
Liraglutide + Risperidone
Severity: Moderate
Liraglutide and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone may raise blood glucose and promote weight gain, which can work against the glycemic benefit of liraglutide. Glycemic control may be less predictable after risperidone is started or adjusted.
What this interaction means in plain words
Liraglutide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liraglutide belongs to Endocrine; Risperidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism: antipsychotic-induced insulin resistance and metabolic effects oppose incretin-mediated glucose lowering.
What to do
Monitor blood glucose, HbA1c and weight regularly, and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Liraglutide with Risperidone?
MediHelp rates the interaction as moderate. Liraglutide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone may raise blood glucose and promote weight gain, which can work against the glycemic benefit of liraglutide. Glycemic control may be less predictable after risperidone is started or adjusted.
How serious is the interaction between Liraglutide and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, HbA1c and weight regularly, and adjust antidiabetic therapy as needed.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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