Drug interactions
Lisdexamfetamine + Maprotiline
Severity: Major
Lisdexamfetamine and Maprotiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline blocks norepinephrine reuptake and amphetamines increase norepinephrine release, so the pressor and cardiac effects may be exaggerated. Both also lower the seizure threshold, and CYP2D6 inhibition may increase amphetamine exposure.
What this interaction means in plain words
Lisdexamfetamine and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lisdexamfetamine belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive noradrenergic stimulation with possible CYP2D6-mediated increase in amphetamine levels.
What to do
Avoid if possible. If used together, start with low doses and monitor blood pressure, heart rate, ECG, and signs of serotonin toxicity or seizures.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Maprotiline?
MediHelp rates the interaction as major. Lisdexamfetamine and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Maprotiline blocks norepinephrine reuptake and amphetamines increase norepinephrine release, so the pressor and cardiac effects may be exaggerated. Both also lower the seizure threshold, and CYP2D6 inhibition may increase amphetamine exposure.
How serious is the interaction between Lisdexamfetamine and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used together, start with low doses and monitor blood pressure, heart rate, ECG, and signs of serotonin toxicity or seizures.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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