Drug interactions
Lisdexamfetamine + Naratriptan
Severity: Moderate
Lisdexamfetamine and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase serotonergic and noradrenergic activity and triptans are serotonin agonists, so serotonin syndrome is theoretically possible. Documented cases are rare. Both drugs can also raise blood pressure or cause vasoconstriction.
What this interaction means in plain words
Lisdexamfetamine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisdexamfetamine belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic activity (amphetamine serotonin release plus 5-HT1B/1D agonism) and additive vasoconstrictive effects.
What to do
Counsel patients to report agitation, tremor, hyperthermia, diarrhea or confusion. Monitor blood pressure and use the lowest triptan dose that works.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Naratriptan?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines increase serotonergic and noradrenergic activity and triptans are serotonin agonists, so serotonin syndrome is theoretically possible. Documented cases are rare. Both drugs can also raise blood pressure or cause vasoconstriction.
How serious is the interaction between Lisdexamfetamine and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report agitation, tremor, hyperthermia, diarrhea or confusion. Monitor blood pressure and use the lowest triptan dose that works.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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