Drug interactions
Lisdexamfetamine + Oxytocin
Severity: Minor
Lisdexamfetamine and Oxytocin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxytocin can cause hypotension or hypertension, and sympathomimetics such as amphetamines may raise blood pressure. In theory the combination could lead to additive pressor effects. This is mainly relevant in obstetric settings.
What this interaction means in plain words
Lisdexamfetamine and Oxytocin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lisdexamfetamine belongs to Central Nervous System; Oxytocin belongs to Endocrine.
Why it happens
Theoretical additive hemodynamic effects; sympathomimetic pressor activity combined with oxytocin's cardiovascular effects.
What to do
Monitor blood pressure and heart rate during oxytocin infusion in patients taking lisdexamfetamine. Treat hypertension per standard obstetric protocols.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Oxytocin
- Carboprost tromethamine + Oxytocin Major
- Dinoprostone + Oxytocin Major
- Ephedrine + Oxytocin Major
- Fexinidazole + Oxytocin Major
- Givinostat + Oxytocin Major
- Misoprostol + Oxytocin Major
Frequently asked questions
Can I take Lisdexamfetamine with Oxytocin?
MediHelp rates the interaction as minor. Lisdexamfetamine and Oxytocin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxytocin can cause hypotension or hypertension, and sympathomimetics such as amphetamines may raise blood pressure. In theory the combination could lead to additive pressor effects. This is mainly relevant in obstetric settings.
How serious is the interaction between Lisdexamfetamine and Oxytocin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during oxytocin infusion in patients taking lisdexamfetamine. Treat hypertension per standard obstetric protocols.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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