Drug interactions
Lisdexamfetamine + Quetiapine
Severity: Moderate
Lisdexamfetamine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is a sedating dopamine and serotonin antagonist while lisdexamfetamine is a stimulant, so their effects on alertness and dopaminergic activity are opposed. The combination is commonly used in practice and is generally manageable. Stimulants may worsen psychosis in susceptible patients.
What this interaction means in plain words
Lisdexamfetamine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisdexamfetamine belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on dopaminergic neurotransmission and arousal.
What to do
Monitor psychiatric symptoms, sedation and heart rate. Titrate each drug to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Lisdexamfetamine with Quetiapine?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is a sedating dopamine and serotonin antagonist while lisdexamfetamine is a stimulant, so their effects on alertness and dopaminergic activity are opposed. The combination is commonly used in practice and is generally manageable. Stimulants may worsen psychosis in susceptible patients.
How serious is the interaction between Lisdexamfetamine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric symptoms, sedation and heart rate. Titrate each drug to clinical response.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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