Drug interactions
Lisdexamfetamine + Secobarbital
Severity: Minor
Lisdexamfetamine and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A sedative barbiturate and a stimulant have opposing effects on alertness. The stimulant may mask sedation without reducing barbiturate impairment, and the net effect is unpredictable.
What this interaction means in plain words
Lisdexamfetamine and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lisdexamfetamine belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
Opposing CNS pharmacodynamic effects; no established pharmacokinetic mechanism.
What to do
Monitor patient for alertness and sleep quality, and do not rely on the stimulant to offset barbiturate sedation. Avoid driving until the response to the combination is known.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Secobarbital?
MediHelp rates the interaction as minor. Lisdexamfetamine and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. A sedative barbiturate and a stimulant have opposing effects on alertness. The stimulant may mask sedation without reducing barbiturate impairment, and the net effect is unpredictable.
How serious is the interaction between Lisdexamfetamine and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor patient for alertness and sleep quality, and do not rely on the stimulant to offset barbiturate sedation. Avoid driving until the response to the combination is known.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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