Drug interactions
Lisdexamfetamine + Sertraline
Severity: Major
Lisdexamfetamine and Sertraline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase synaptic serotonin, and combined use with an SSRI may precipitate serotonin syndrome. Features include agitation, tremor, hyperthermia, diarrhea and neuromuscular hyperactivity.
What this interaction means in plain words
Lisdexamfetamine and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lisdexamfetamine belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive serotonergic activity; sertraline may also modestly raise amphetamine exposure through CYP2D6 inhibition.
What to do
Start lisdexamfetamine at a low dose and titrate slowly while monitoring for serotonin toxicity. Stop the serotonergic agents and give supportive care if serotonin syndrome develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Sertraline?
MediHelp rates the interaction as major. Lisdexamfetamine and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amphetamines increase synaptic serotonin, and combined use with an SSRI may precipitate serotonin syndrome. Features include agitation, tremor, hyperthermia, diarrhea and neuromuscular hyperactivity.
How serious is the interaction between Lisdexamfetamine and Sertraline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start lisdexamfetamine at a low dose and titrate slowly while monitoring for serotonin toxicity. Stop the serotonergic agents and give supportive care if serotonin syndrome develops.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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