Drug interactions
Lisdexamfetamine + Sufentanil
Severity: Moderate
Lisdexamfetamine and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a potent opioid causing sedation and respiratory depression, while lisdexamfetamine is a stimulant that may mask drowsiness but does not reliably reverse respiratory depression. Some opioids also have serotonergic activity, though sufentanil has little. Perioperative use needs attention to cardiovascular stability.
What this interaction means in plain words
Lisdexamfetamine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisdexamfetamine belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Opposing CNS effects with additional sympathomimetic cardiovascular effects; no pharmacokinetic interaction is established.
What to do
Monitor respiratory status and sedation based on objective measures rather than alertness. Inform the anesthesia team about stimulant use before procedures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Lisdexamfetamine with Sufentanil?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is a potent opioid causing sedation and respiratory depression, while lisdexamfetamine is a stimulant that may mask drowsiness but does not reliably reverse respiratory depression. Some opioids also have serotonergic activity, though sufentanil has little. Perioperative use needs attention to cardiovascular stability.
How serious is the interaction between Lisdexamfetamine and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory status and sedation based on objective measures rather than alertness. Inform the anesthesia team about stimulant use before procedures.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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