Drug interactions
Lisdexamfetamine + Sumatriptan
Severity: Moderate
Lisdexamfetamine and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase serotonin and norepinephrine release and sumatriptan is a serotonin agonist, so serotonin syndrome is theoretically possible, though documented cases are uncommon. Both can raise blood pressure or cause vasoconstriction.
What this interaction means in plain words
Lisdexamfetamine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisdexamfetamine belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic and vasoconstrictive effects.
What to do
Advise patients to report signs of serotonin toxicity such as agitation, tremor, hyperthermia or diarrhea. Monitor blood pressure, especially with first co-administration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Sumatriptan?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines increase serotonin and norepinephrine release and sumatriptan is a serotonin agonist, so serotonin syndrome is theoretically possible, though documented cases are uncommon. Both can raise blood pressure or cause vasoconstriction.
How serious is the interaction between Lisdexamfetamine and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report signs of serotonin toxicity such as agitation, tremor, hyperthermia or diarrhea. Monitor blood pressure, especially with first co-administration.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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