Drug interactions
Lisdexamfetamine + Tranylcypromine
Severity: Contraindicated
Lisdexamfetamine and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines given with MAO inhibitors can precipitate hypertensive crisis because of massive norepinephrine release, and serotonin syndrome is also possible. Outcomes include severe headache, stroke and death.
What this interaction means in plain words
Lisdexamfetamine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lisdexamfetamine belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAO inhibition prevents breakdown of monoamines released by amphetamine, causing excessive catecholamine and serotonin accumulation.
What to do
Do not use together or within 14 days of stopping the MAO inhibitor. Choose a non-stimulant alternative if ADHD treatment is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Lisdexamfetamine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amphetamines given with MAO inhibitors can precipitate hypertensive crisis because of massive norepinephrine release, and serotonin syndrome is also possible. Outcomes include severe headache, stroke and death.
How serious is the interaction between Lisdexamfetamine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together or within 14 days of stopping the MAO inhibitor. Choose a non-stimulant alternative if ADHD treatment is needed.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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