Drug interactions
Lisdexamfetamine + Ziprasidone
Severity: Moderate
Lisdexamfetamine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone blocks dopamine receptors and prolongs the QT interval, while lisdexamfetamine is stimulating and raises heart rate and blood pressure. Their central effects oppose one another, and the cardiac effects may be additive in at-risk patients.
What this interaction means in plain words
Lisdexamfetamine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisdexamfetamine belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Opposing dopaminergic effects with potential additive cardiac effects (QT prolongation plus sympathomimetic stimulation).
What to do
Consider baseline ECG and electrolytes in patients with cardiac risk factors. Monitor heart rate, psychiatric symptoms and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Ziprasidone?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone blocks dopamine receptors and prolongs the QT interval, while lisdexamfetamine is stimulating and raises heart rate and blood pressure. Their central effects oppose one another, and the cardiac effects may be additive in at-risk patients.
How serious is the interaction between Lisdexamfetamine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider baseline ECG and electrolytes in patients with cardiac risk factors. Monitor heart rate, psychiatric symptoms and sedation.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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