Drug interactions
Lisinopril + Silodosin
Severity: Moderate
Lisinopril and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Silodosin is an alpha-1A blocker and lisinopril is an ACE inhibitor, so both lower blood pressure by different routes. Together they can increase the risk of symptomatic hypotension, dizziness and syncope, particularly at treatment initiation or after dose increases.
What this interaction means in plain words
Lisinopril and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisinopril belongs to Cardiovascular; Silodosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic hypotensive effects from alpha-1 adrenergic blockade and inhibition of angiotensin II formation.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug, and counsel the patient to rise slowly. Reduce the dose of one agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Silodosin?
MediHelp rates the interaction as moderate. Lisinopril and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Silodosin is an alpha-1A blocker and lisinopril is an ACE inhibitor, so both lower blood pressure by different routes. Together they can increase the risk of symptomatic hypotension, dizziness and syncope, particularly at treatment initiation or after dose increases.
How serious is the interaction between Lisinopril and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug, and counsel the patient to rise slowly. Reduce the dose of one agent if symptomatic hypotension occurs.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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