Drug interactions
Lofexidine + Rolapitant
Severity: Moderate
Lofexidine and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant is a long-acting inhibitor of CYP2D6, and lofexidine is cleared in part by CYP2D6. Lofexidine exposure may increase, leading to hypotension, orthostasis and bradycardia. The inhibition persists for days to weeks after a rolapitant dose.
What this interaction means in plain words
Lofexidine and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, reducing the metabolism of lofexidine.
What to do
Monitor blood pressure and heart rate and counsel on orthostatic symptoms. Consider reducing the lofexidine dose, remembering that the inhibition outlasts the rolapitant dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lofexidine and Rolapitant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Rolapitant?
MediHelp rates the interaction as moderate. Lofexidine and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rolapitant is a long-acting inhibitor of CYP2D6, and lofexidine is cleared in part by CYP2D6. Lofexidine exposure may increase, leading to hypotension, orthostasis and bradycardia. The inhibition persists for days to weeks after a rolapitant dose.
How serious is the interaction between Lofexidine and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and counsel on orthostatic symptoms. Consider reducing the lofexidine dose, remembering that the inhibition outlasts the rolapitant dose.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
