Drug interactions
Lomitapide + Ondansetron
Severity: Minor
Lomitapide and Ondansetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide inhibits P-glycoprotein and could raise exposure to P-gp substrates. Ondansetron is a P-gp substrate, so its concentrations and QT effect may increase modestly.
What this interaction means in plain words
Lomitapide and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lomitapide belongs to Cardiovascular; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
P-glycoprotein inhibition by lomitapide may reduce ondansetron efflux.
What to do
Use the lowest effective ondansetron dose and monitor for adverse effects such as QT prolongation in patients with risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Ondansetron?
MediHelp rates the interaction as minor. Lomitapide and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lomitapide inhibits P-glycoprotein and could raise exposure to P-gp substrates. Ondansetron is a P-gp substrate, so its concentrations and QT effect may increase modestly.
How serious is the interaction between Lomitapide and Ondansetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective ondansetron dose and monitor for adverse effects such as QT prolongation in patients with risk factors.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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