Drug interactions
Lomitapide + Pravastatin
Severity: Moderate
Lomitapide and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide may raise pravastatin levels, and both drugs can affect the liver. Together they may increase the risk of muscle toxicity and raised transaminases.
What this interaction means in plain words
Lomitapide and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Pravastatin belongs to Cardiovascular.
Why it happens
Lomitapide inhibits P-glycoprotein, increasing pravastatin absorption; additive hepatotoxic potential.
What to do
Monitor liver enzymes and muscle symptoms, and consider a lower pravastatin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Pravastatin?
MediHelp rates the interaction as moderate. Lomitapide and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide may raise pravastatin levels, and both drugs can affect the liver. Together they may increase the risk of muscle toxicity and raised transaminases.
How serious is the interaction between Lomitapide and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and muscle symptoms, and consider a lower pravastatin dose if needed.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporin, Gemfibrozil, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Pravastatin page.
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