Drug interactions
Lomitapide + Temsirolimus
Severity: Moderate
Lomitapide and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide inhibits P-glycoprotein and may increase temsirolimus exposure. Temsirolimus may in turn have effects on lomitapide, which is a sensitive CYP3A4 substrate. Both drugs can cause adverse effects such as gastrointestinal intolerance and raised liver enzymes.
What this interaction means in plain words
Lomitapide and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
Lomitapide inhibits P-glycoprotein efflux of temsirolimus, and the two drugs may share CYP3A4 handling.
What to do
Monitor liver enzymes and temsirolimus toxicity, and consider reducing the temsirolimus dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Temsirolimus?
MediHelp rates the interaction as moderate. Lomitapide and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide inhibits P-glycoprotein and may increase temsirolimus exposure. Temsirolimus may in turn have effects on lomitapide, which is a sensitive CYP3A4 substrate. Both drugs can cause adverse effects such as gastrointestinal intolerance and raised liver enzymes.
How serious is the interaction between Lomitapide and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and temsirolimus toxicity, and consider reducing the temsirolimus dose if adverse effects occur.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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