Drug interactions
Lomustine + Pneumococcal vaccine 13-valent
Severity: Moderate
Lomustine and Pneumococcal vaccine 13-valent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine-related immunosuppression can diminish the antibody response to the conjugate pneumococcal vaccine, leaving patients more exposed to pneumococcal disease.
What this interaction means in plain words
Lomustine and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomustine belongs to Oncology; Pneumococcal vaccine 13-valent belongs to Miscellaneous.
Why it happens
Cytotoxic suppression of lymphocyte function reduces vaccine immunogenicity.
What to do
Administer the vaccine at least 2 weeks before lomustine when feasible. If given during therapy, plan revaccination at least 3 months after treatment is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Frequently asked questions
Can I take Lomustine with Pneumococcal vaccine 13-valent?
MediHelp rates the interaction as moderate. Lomustine and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine-related immunosuppression can diminish the antibody response to the conjugate pneumococcal vaccine, leaving patients more exposed to pneumococcal disease.
How serious is the interaction between Lomustine and Pneumococcal vaccine 13-valent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Administer the vaccine at least 2 weeks before lomustine when feasible. If given during therapy, plan revaccination at least 3 months after treatment is stopped.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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